Cartilage, bone and synovial histomorphometry in animal models of osteoarthritis
نویسندگان
چکیده
منابع مشابه
Subchondral Bone Plate Thickening Precedes Chondrocyte Apoptosis and Cartilage Degradation in Spontaneous Animal Models of Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder characterised by bone remodelling and cartilage degradation and associated with chondrocyte apoptosis. These processes were investigated at 10, 16, 24, and 30 weeks in Dunkin Hartley (DH) and Bristol Strain 2 (BS2) guinea pigs that develop OA spontaneously. Both strains had a more pronounced chondrocyte apoptosis, cartilage degradation, and ...
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We have recently shown that IL-29 was an important proinflammatory cytokine in pathogenesis of rheumatoid arthritis (RA). Inflammation also contributes to the pathogenesis of osteoarthritis (OA). The aim of this study was to investigate the effect and mechanism of IL-29 on cytokine production and cartilage degradation in OA. The mRNA levels of IL-29 and its specific receptor IL-28Ra in peripher...
متن کاملCartilage markers in synovial fluid in symptomatic knee osteoarthritis.
OBJECTIVE To investigate if the relative content of aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid lavage samples differs between individuals with knee pain with or without evidence of radiological knee osteoarthritis (joint space narrowing). METHODS In a community based cohort of 204 individuals aged 35-54 years with chronic (> 3 months duration) knee pain, a subgr...
متن کاملAnimal models of osteoarthritis.
Animal models of osteoarthritis are used to study the pathogenesis of cartilage degeneration and to evaluate potential antiarthritic drugs for clinical use. Animal models of naturally occurring osteoarthritis (OA) occur in knee joints of guinea pigs, mice and other laboratory animal species. Transgenic models have been developed in mice. Commonly utilized surgical instability models include med...
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In the development process of drugs for different diseases the pharmaceutical companies spend a lot of resources in the preclinical phase when researching for compounds as drug candidates. In the matter of osteoarthritis (degenerative joint disease), part of the research includes test on mice which spontaneously develop the disease. It is difficult to determine the level of osteoarthritis (OA) ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2010
ISSN: 1063-4584
DOI: 10.1016/j.joca.2010.05.024